Evidence map›Paper›PMID 42167232›Full record

ArticleCell reports. Medicine2026

Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.

Shuailin Li, Hazel Morrison, Mihaela Duta, Julia L Marshall, Stephanie A Harris, Wanlin He, Alberta Ateere, Beatrice Nassanga, Iman Satti, Helen McShane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuailin LiJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Hazel MorrisonJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Mihaela DutaOxford Research Software Engineering Group, Doctoral Training Centre, University of Oxford, Oxford OX1 3NP, UK.
Julia L MarshallJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Stephanie A HarrisJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Wanlin HeCenter for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Alberta AteereJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Beatrice NassangaJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Iman SattiJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Helen McShaneJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: helen.mcshane@ndm.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) vaccine development is hindered by limited understanding of human immune responses to Mycobacterium tuberculosis. Using an aerosolized Mycobacterium bovis BCG human challenge model, we perform single-cell and bulk immune profiling of bronchoalveolar lavage and blood samples to define the temporal immune dynamics in BCG-naive individuals. Rapid changes in cellular composition and gene expression occur in both compartments, with TB-associated gene signatures evident on days 2 and 7 post-challenge. T cell receptor clones that expand in blood at day 7 persist in the lung mucosa until day 56 and are often detectable in blood before challenge. Pre-existing expanded clones are more enriched for activated CD4

Indexed as

BCG VaccineImmunity, MucosalLungMycobacterium bovisSingle-Cell AnalysisTuberculosisAerosolsCD4-Positive T-LymphocytesHuman Challenge Trials as TopicHumansMycobacterium tuberculosisReceptors, Antigen, T-CellAerosolsBCG VaccineReceptors, Antigen, T-CellBCGcontrolled human infection modelmucosal immunityT cell receptortuberculosis

Identifiers

PMID42167232
PMCPMC13293970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.