Evidence map›Paper›PMID 42167221›Full record

ArticleStem cell reports2026

Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury.

Mickey E Abraham, Joel R Martin, Margaret Seaton, Michael G Brandel, Kiefer J Forseth, Catriona Jamieson, Martin Marsala, Joseph D Ciacci

Abstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mickey E AbrahamDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA.
Joel R MartinDepartment of Neurological Surgery, Orlando Health, Orlando, FL 32806, USA.
Margaret SeatonDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA.
Michael G BrandelDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA.
Kiefer J ForsethDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA.
Catriona JamiesonDepartment of Medicine, Division of Regenerative Medicine and CIRM Alpha Stem Cell Clinic, University of California, San Diego, La Jolla, CA 92037, USA.
Martin MarsalaDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA 92037, USA.
Joseph D CiacciDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: jciacci@ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem cell transplantation offers a promising avenue for spinal cord injury (SCI) repair, but demonstrating safety and feasibility in human populations remains a critical step. In this phase 1 trial, we investigate the long-term outcomes of cervical spinal cord implantation of NSI-566, a human spinal cord-derived neural stem cell line. With prospective data collection over 60 months, we assess adverse events, functional outcomes, and neurophysiological measures in a small cohort (N = 3) of chronic AIS-A SCI patients. We report a favorable safety profile with no evidence of tumorigenicity or procedure-related complications. Subclinical neurophysiological changes and limited functional gains were observed, although interpretation is constrained by the absence of a control group and the confounding effects of post-operative rehabilitation. These findings support the feasibility of intraparenchymal stem cell delivery for chronic SCI and underscore the need for larger, controlled trials to clarify efficacy and optimize therapeutic parameters.

Indexed as

Cervical CordNeural Stem CellsSpinal Cord InjuriesStem Cell TransplantationAdultCervical VertebraeChronic DiseaseHumansMaleMiddle AgedRecovery of FunctionTreatment OutcomeYoung Adultclinical trialintraspinalneural stem cellsspinal cord injuryspinestem cells

Identifiers

PMID42167221
PMCPMC13261865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.