Evidence map›Paper›PMID 42167124›Full record

ArticleEBioMedicine2026

Association of serum biomarkers of dietary purine intake with glycaemic control and risk of preterm birth: two prospective cohort studies among pregnant women.

Shijia Hu, Zelei Miao, Yidan Dong, Yuwei Lai, Ke Zhang, Congmei Xiao, Jingnan Chen, Wanglong Gou, Yuanqing Fu, Tianlei Wang and 11 more

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Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Shijia HuSchool of Life Sciences, Fudan University, Shanghai, China; Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Zelei MiaoAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Yidan DongSection of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Yuwei LaiDepartment of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ke ZhangAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Congmei XiaoAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Jingnan ChenAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Wanglong GouAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Yuanqing FuAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Tianlei WangSection of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Fan LiSection of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Mei-Qi ShiDepartment of Obstetrics and Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China; Department of Obstetrics and Gynecology, The Affiliated Hangzhou Women's Hospital of Hangzhou Normal University, Hangzhou, China.
Sha LuDepartment of Obstetrics and Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China; Department of Obstetrics and Gynecology, The Affiliated Hangzhou Women's Hospital of Hangzhou Normal University, Hangzhou, China.
Xu-Hong WangDepartment of Obstetrics and Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China; Department of Obstetrics and Gynecology, The Affiliated Hangzhou Women's Hospital of Hangzhou Normal University, Hangzhou, China.
Jiaying YuanDepartment of Science and Education, Shuangliu Maternal and Child Health Hospital, Chengdu, China.
Jin WuDepartment of Pediatrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
An PanDepartment of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wensheng HuWomen's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hongjun ShiAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xiong-Fei PanSection of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: pxiongfei@scu.edu.cn.
Ju-Sheng ZhengAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China; Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China; Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, School of Medicine, Westlake University, Hangzhou, China. Electronic address: zhengjusheng@westlake.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo examine serum purine metabolites as biomarkers of maternal dietary purine intake and their associations with glycaemic control and preterm birth during pregnancy.

methodsWe included 1480 pregnant Chinese women with gestational diabetes mellitus (GDM) from the Westlake Precision Birth Cohort (WeBirth) at mid-pregnancy, divided into discovery (n = 1230) and internal validation (n = 250) subcohorts. Linear regression was used to assess associations between serum metabolites, dietary purine intake, and continuous glucose monitoring (CGM) metrics. A purine score was developed and evaluated for associations with glycaemic control and preterm birth, with replication in 936 pregnant women from the Tongji-Huaxi-Shuangliu Birth Cohort (THSBC).

findingsSerum purine level was associated with dietary purine intake and with the mean of daily difference (β = 0.096 [95% CI, 0.038, 0.15]). The association between higher serum purine and preterm birth risk in the WeBirth cohort (OR = 1.29 [95% CI, 1.06, 1.52]) was replicated in the THSBC cohort. Early-pregnancy serum purine also predicted GDM risk (OR = 1.38 [95% CI, 1.13, 1.63]) in the THSBC. A purine score comprising purine, adenine, 6-O-methylguanine, and uric acid showed consistent associations with glycaemic variability and preterm birth across both cohorts.

interpretationReflecting dietary purine intake, serum purine level and purine score are associated with greater glycaemic variability and higher preterm birth risk. Monitoring dietary purine intake may improve glycaemic control in GDM and prevent pregnancy complications.

fundingNational Key R&D Program of China; National Natural Science Foundation of China; Zhejiang Provincial Key Laboratory Construction Project; Sichuan Provincial Natural Science Foundation.

Indexed as

BiomarkersDiabetes, GestationalDietGlycemic ControlPremature BirthPurinesAdultBlood GlucoseFemaleHumansPregnancyProspective StudiesRisk FactorsBiomarkersBlood GlucosePurinesContinuous glucose monitoring (CGM)Dietary purine intakeGestational diabetes mellitus (GDM)Preterm birthSerum biomarkers

Identifiers

PMID42167124
PMCPMC13199657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.