Evidence map›Paper›PMID 42167025›Full record

ReviewInternational dental journal2026

Advances in Nanozyme Engineering for Precision Oral Health Management.

Fan Tong, Feifei Feng, Lingyi Zhang, Feifei Lu, Zitong Liu, Xinyu Lin, Nan Xiao, Yuanyuan Han, Chang Shen, Yulai Wang and 5 more

Abstract readReview
In one paragraph

Review in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A biomimetic urchin-like photothermal nanoplatform for the efficient eradication ofFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fan TongCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Feifei FengThe Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Lingyi ZhangCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Feifei LuCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Zitong LiuCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Xinyu LinCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Nan XiaoCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Yuanyuan HanCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Chang ShenCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Yulai WangCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Anqi ShengJilin Province Science and Technology Fund Operation Service Center, Changchun, China; College of Life Science and Technology, Changchun University of Science and Technology, Changchun, China.
Xinglong LiuCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.
Kun WeiClinical Medical Laboratory Science, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China. Electronic address: emptyzykk@163.com.
Ting ZhaoCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China. Electronic address: zhaotingting@jlnku.edu.cn.
Chuanbo DingCollege of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China. Electronic address: dingchuanbo@jlnku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimsDespite recent advances in dental care, traditional treatments suffer from poor targeting, limited stability, and unsatisfactory regenerative efficacy. This review aims to clarify the multi-level intervention targets of nanozymes for oral diseases, highlight their unique merits over conventional strategies, and provide a theoretical basis for developing novel precision oral therapeutic systems.

methodsHigh-quality literature was retrieved from PubMed, Web of Science, and other core databases, including in vitro, in vivo, and emerging clinical studies on the design, function, and applications of nanozymes in oral diseases.

conclusionsNanozymes demonstrate significant potential for targeted antibacterial therapy, oxidative stress regulation, and tissue repair within the complex oral microenvironment. Their integration with advanced delivery platforms enhances therapeutic precision. Future development should focus on multi-enzyme synergistic systems, improved biocompatibility, and clinical translation to realize their promise in precision oral medicine. CLINICAL SIGNIFICANCE: Nanozymes represent a paradigm shift from passive to active, dynamic oral therapeutics. They offer a promising strategy for managing biofilm-associated diseases (caries, periodontitis) and complex conditions (oral mucositis, cancer) with enhanced specificity and regenerative potential, potentially reducing antibiotic reliance and improving long-term treatment outcomes.

Indexed as

Mouth DiseasesNanostructuresOral HealthPrecision MedicineDrug Delivery SystemsHumansDrug delivery platformNanozymesOral DiseasesTissue repair

Identifiers

PMID42167025
PMCPMC13217486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.