Evidence map›Paper›PMID 42166647›Full record

ReviewChemical reviews2026

Metal-Catalyzed Reductive Coupling of Aryl Halides beyond Premetalated Reagents or Metallic Reductants: Biaryl Formation.

Yoon Cho, Yu-Hsiang Chang, Weijia Shen, Michael J Krische

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoon ChoDepartment of Chemistry, University of Texas at Austin, Welch Hall (A5300), 105 E 24th St., Austin, Texas 78712, United States.ORCID 0000-0002-3550-6699
Yu-Hsiang ChangDepartment of Chemistry, University of Texas at Austin, Welch Hall (A5300), 105 E 24th St., Austin, Texas 78712, United States.
Weijia ShenDepartment of Chemistry, University of Texas at Austin, Welch Hall (A5300), 105 E 24th St., Austin, Texas 78712, United States.ORCID 0000-0001-6345-3371
Michael J KrischeDepartment of Chemistry, University of Texas at Austin, Welch Hall (A5300), 105 E 24th St., Austin, Texas 78712, United States.ORCID 0000-0001-8418-9709

Funding

Catalytic C-C Coupling via Hydrogen TransferR35GM155947 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MICHAEL J KRISCHE · 2025 to 2026
$1.1M
NIGMS NIH HHS R35 GM155947
6 · The paper itself

Abstract

Biaryl motifs figure prominently in commercial pharmaceutical and agrochemical ingredients and are used widely in organic optoelectronic materials. Traditional palladium-catalyzed cross-coupling reactions, such as Suzuki, Negishi and Stille couplings, are powerful methods for aryl-aryl bond formation, but their reliance on premetalated reagents poses practical limitations. As most arylmetal reagents derive from the corresponding aryl halides, considerable effort has been devoted to the development of direct catalytic aryl halide reductive couplings. However, most methods require metallic reductants. In this monograph, metal-catalyzed aryl halide reductive homocouplings (Ullmann reactions) and cross-couplings mediated by nonmetallic reductants are surveyed.

Identifiers

PMID42166647
PMCPMC13283440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.