Evidence map›Paper›PMID 42166566›Full record

ArticleACS applied materials & interfaces2026

Injectable Microenvironment-Responsive Hydrogel for Local Procyanidin B2 Delivery and Cardiac Ischemia-Reperfusion Repair.

Sida Qin, Xu Zhan, Haobo Sun, Yang Liu, Yu Zhang, Wenxi Zhang, Donghui Liu, Fukai Liu, Yanghong Xue, Erjun Zhu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sida QinDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Xu ZhanDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Haobo SunDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Yang LiuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Yu ZhangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Wenxi ZhangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Donghui LiuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Fukai LiuAnimal Laboratory Center, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Yanghong XueDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Erjun ZhuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Guofu ZhangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Weixin MengDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Lei XuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Dongyun QiuDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Chao ChiDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Jiyi ZhaoDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Lihua SunDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, and Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Kai KangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.ORCID 0009-0008-6413-9630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (IR) injury is a key pathological process that causes adverse outcomes following revascularization in acute myocardial infarction. This process is mainly driven by mitochondrial dysfunction, oxidative stress, and inflammatory cascades. Although procyanidin B2 (PCB2), a natural polyphenol, exhibits strong antioxidant and anti-inflammatory properties, its clinical use remains limited due to poor targeting, unfavorable pharmacokinetics, and oxidative instability. Herein, we developed a dual pH- and reactive oxygen species-responsive hydrogel (poly(vinyl alcohol)-TSPBA [

Indexed as

AntioxidantsBiflavonoidsCatechinHydrogelsMyocardial Reperfusion InjuryProanthocyanidinsAnimalsCell LineMaleMyocytes, CardiacOxidative StressRatsRats, Sprague-DawleyAntioxidantsBiflavonoidsCatechinHydrogelsProanthocyanidinsprocyanidin B2dual-responsive hydrogelischemia−reperfusion injurymitochondrial dysfunctionoxidative stressprocyanidin B2

Identifiers

PMID42166566
PMCPMC13244373

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.