Evidence map›Paper›PMID 42166367›Full record

ArticleChemistry & biodiversity2026

An Unusual Spiro-Fused Indole Alkaloid-Terrein Hybrid From Marine-Derived Fungus Aspergillus chevalieri HK-56.

WanJuan Xie, XuHua Nong, YiLin Kuang, Hong Xiao, YanLing Ma, XueMing Zhou, YongMin Zhang, GuangYing Chen

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

WanJuan XieKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
XuHua NongKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
YiLin KuangKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
Hong XiaoKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
YanLing MaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
XueMing ZhouKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
YongMin ZhangKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
GuangYing ChenKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.ORCID https://orcid.org/0000-0002-6729-0597

Funding

National Natural Science Foundation of China 22177023National Natural Science Foundation of China 22477021
6 · The paper itself

Abstract

One previously undescribed alkaloid variecoterrein (1) and seven known compounds (2-8) were obtained from the solid-state fermentation culture of the marine-derived fungus Aspergillus chevalieri HK-56. The planar and stereochemical structures of 1 was unambiguously elucidated by comprehensive spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS), DP4+ probability analysis, and electronic circular dichroism (ECD) spectroscopy. Compound 1 represents a structurally unique hybrid molecule, constituting the first naturally occurring conjugate that incorporates both indole 2,5-diketopiperazine alkaloid and terrein structural scaffolds. All isolated compounds were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cells. Among them, compound 2 exhibited potent in vitro anti-inflammatory activity, with an IC

Indexed as

Anti-Inflammatory AgentsAspergillusIndole AlkaloidsSpiro CompoundsAlkaloidsAnimalsCyclopentanesLipopolysaccharidesMacrophagesMiceMolecular ConformationMolecular StructureNitric OxideRAW 264.7 CellsStructure-Activity RelationshipAlkaloidsAnti-Inflammatory AgentsCyclopentanesIndole AlkaloidsLipopolysaccharidesNitric OxideSpiro Compoundsterreinalkaloidsanti‐inflammatory activityAspergillus chevalieri HK‐56marine‐derived fungi

Identifiers

PMID42166367
PMCPMC13380992

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