Evidence map›Paper›PMID 42166216›Full record

ArticleeLife2026

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation.

Dana M S Cheung, Momchil Razsolkov, Fabrizia Bonacina, Stephen Andrews, Megan C Sumoreeah, Linda V Sinclair, Andrew J M Howden, J Simon C Arthur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana M S CheungDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0003-4920-8876
Momchil RazsolkovDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.
Fabrizia BonacinaDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-2611-1177
Stephen AndrewsDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.
Megan C SumoreeahDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-3275-3344
Linda V SinclairDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0003-1248-7189
Andrew J M HowdenDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-4332-9469
J Simon C ArthurDivision of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-8135-1958

Funding

Medical Research Council MR/N013735/1Wellcome Trust UNS148487
6 · The paper itself

Abstract

Naive B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as physiological stimuli to initiate this transition. Using quantitative proteomics, we show that TLR4 engagement induces metabolic reprogramming in murine B cells, increasing the expression of amino acid transporters and cholesterol biosynthetic enzymes. The amino acid transporter SLC7A5 is markedly upregulated following LPS stimulation, and conditional deletion of

Indexed as

B-LymphocytesCell ProliferationLarge Neutral Amino Acid-Transporter 1LipopolysaccharidesLymphocyte ActivationToll-Like ReceptorsAnimalsCholesterolGene DeletionHydroxymethylglutaryl-CoA Reductase InhibitorsMiceMice, Inbred C57BLToll-Like Receptor 4CholesterolHydroxymethylglutaryl-CoA Reductase InhibitorsLarge Neutral Amino Acid-Transporter 1LipopolysaccharidesSlc7a5 protein, mouseTlr4 protein, mouseToll-Like Receptor 4Toll-Like ReceptorsB cellcholesterolimmunologyinflammationmousestatintoll-like receptor

Identifiers

PMID42166216
PMCPMC13193715

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.