Evidence map›Paper›PMID 42165992›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2026

Transcription Factor TBX5 Enhances Structural Complexity and Calcium Transient Synchronization in Spontaneously Active Neonatal Rat Cardiomyocyte Cultures.

O B Pustovit, M K Nifontova, Ya A Voronina, A N Anisenko, M B Gottikh, V S Kuzmin

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

O B PustovitBiological Faculty, Moscow State University, Moscow, Russia. k_pustovit@mail.ru.
M K NifontovaBiological Faculty, Moscow State University, Moscow, Russia.
Ya A VoroninaBiological Faculty, Moscow State University, Moscow, Russia.
A N AnisenkoChemical Faculty, Moscow State University, Moscow, Russia.
M B GottikhChemical Faculty, Moscow State University, Moscow, Russia.
V S KuzminBiological Faculty, Moscow State University, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transduced cardiomyocyte-based constructs provide a promising platform for in vitro modeling cardiac disease and a source of cell products for treating cardiac diseases and, particularly, conduction system disorders. Neonatal rat cardiomyocyte cultures were transduced with a vector carrying a gene for the TBX5 transcription factor, which is involved in controlling the bioelectrical properties of cardiomyocytes. TBX5 overexpression was found to increase the number of functionally active cardiomyocyte clusters in a culture, to enhance their morphological complexity, to stimulate the establishment of a mature pattern of calcium dynamics, to synchronize spontaneous Ca

Indexed as

CalciumCalcium SignalingMyocytes, CardiacT-Box Domain ProteinsAnimalsAnimals, NewbornCells, CulturedRatsCalciumT-Box Domain ProteinsT-box transcription factor 5cardiac automaticitycardiomyocytespacemakertissue-engineered constructstranscription factorsСа2+ transients

Identifiers

PMID42165992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.