Evidence map›Paper›PMID 42165960›Full record

ReviewJournal of physiology and biochemistry2026

The progress of mitochondrial function and transfer in stem cell regulation and therapy.

Yubing Zhang, Zhuojian Qu, Zhiliang Guo, Lijuan Zhang, Hong Li, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Wenxu Wang, Min Cheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yubing Zhang *School of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Zhuojian Qu *School of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Zhiliang Guo *The 80th Group Army Hospital of Chinese PLA, Weifang, 261021, China.
Lijuan ZhangWeifang No.2 People's Hospital, Weifang, 261041, China.
Hong LiSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Xiaoyun ZhangSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Xiumei GuanSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Xiaodong CuiSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Wenxu WangSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China.
Min ChengSchool of Basic Medicine Sciences, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, 261053, China. mincheng@sdsmu.edu.cn.

Funding

Weifang Science and Technology Development Projects 2023YX092
6 · The paper itself

Abstract

Mitochondria, serving as central organelles for energy metabolism, play a critical regulatory role in stem cell self-renewal and differentiation-a function increasingly supported by accumulating evidence and closely linked to various aging-related diseases. Central to their function in stem cell pluripotency are several key mechanisms, such as the control of reactive oxygen species, mitophagy, and mitochondrial-endoplasmic reticulum communication. Mitochondrial transfer, as an emerging intercellular communication mechanism, can enhance stem cell pluripotency and function by replacing damaged mitochondria or activating mitophagy in recipient cells. However, different transfer mechanisms can induce distinct effects on recipient cells. The development of artificial mitochondrial transfer technology, compared to traditional cell transplantation, reduces immune rejection and offers new strategies for stem cell therapy. This review examines the interplay between mitochondrial function and stem cell fate determination, discusses the therapeutic potential of mitochondrial transfer in stem cell-based regenerative strategies, and establishes a theoretical framework for understanding and treating mitochondrial dysfunctions and aging-associated pathologies.

Indexed as

MitochondriaStem CellsStem Cell TransplantationAgingAnimalsCell DifferentiationHumansMitophagyReactive Oxygen SpeciesReactive Oxygen SpeciesMitochondrial functionMitochondrial transferMitophagyReactive oxygen speciesStem cell regulation

Identifiers

PMID42165960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.