Molecular insights into induction of apoptosis and regulation of cell cycle proliferation by cycloartane triterpenoids from Dysoxylum malabaricum in breast cancer cells.

Vivek Kumar Sharma, Pooja Goswami, Nivedita Bhardwaj, Shreyans Kumar Jain, Anup Paul, Biplob Koch

Abstract read

In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Vivek Kumar Sharma *Genotoxicology and Cancer Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Pooja Goswami *Genotoxicology and Cancer Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Nivedita BhardwajDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India.

Shreyans Kumar JainDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India.

Anup PaulPortalegre Poletechnic University, Politecnico de Portalegre, Portalegre, Portugal.

Biplob KochGenotoxicology and Cancer Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. biplob@bhu.ac.in.

Funding

Banaras Hindu University File No. R/Dev/D/IoE/Incentive/2021-22/32449University Grants Commission 201610012618University Grants Commission 211610047832

6 · The paper itself

Abstract

Cycloartane triterpenoids (CATT), natural compounds derived from Dysoxylum malabaricum, have substantiated promising anticancer potential, specifically against breast adenocarcinoma T-47D cells. However, the underlying mechanisms of action remain largely unexplored. The present work investigated the antiproliferative and pro-apoptotic effects of CATT on human breast cancer cells both in vitro and in vivo. CATT exhibited potent cytotoxicity against T-47D cells (IC

Indexed as

ApoptosisBreast NeoplasmsCell CycleMeliaceaeTriterpenesAnimalsCell Line, TumorCell ProliferationFemaleHumansMiceMice, Inbred BALB CMitochondriaMolecular Docking SimulationReactive Oxygen SpeciesXenograft Model Antitumor AssayscycloartaneReactive Oxygen SpeciesTriterpenesApoptosisBreast adenocarcinomaCancerCycloartane triterpenoidsDocetaxelDysoxylum malabaricum

Identifiers

PMID42165934

DOI10.3892/or_00000689

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.