Insectivores exhibit superior microbial network connectivity and elevated zoonotic risk by 2035 relative to rodents and bats.

Wild small mammals represent critical sources of zoonotic infections due to their high diversity, global distribution, and proximity to humans. Nevertheless, significant knowledge gaps persist in characterizing pan-taxonomic microbial richness and sharing dynamics, particularly regarding ecologically critical yet understudied Eulipotyphla (true insectivores). Here, we take a macroecological approach to compare how microbial hosting and sharing dynamics differ across insectivores, rodents, and bats, and what ecological factors drive such disparities. We find that insectivores host comparable microbial richness to rodents and bats while exhibiting superior connectivity in microbe-sharing networks, suggesting a higher potential for intra- and cross-order microbial transmission. Urban adaptation, geographic range area, and longevity are shared drivers of microbial richness and sharing across these host orders, while greater body mass and shorter gestation time specifically are positive predictors of these outcomes within insectivores. Climate change projections identify insectivores as primary transmission hosts in new high-latitude hotspots by 2035, including parts of the US, Canada, and Russia, posing greater zoonotic threats than rodents or bats. Our findings challenge the prevailing paradigm that prioritizes rodents and bats as special zoonotic reservoirs, establishing insectivores as critical but overlooked players in disease ecology. Collective proactive surveillance of insectivores, rodents, and bats is imperative for forecasting emerging zoonotic threats and informing global risk assessment frameworks.