SynthesisInternational journal of colorectal disease2026
Microsatellite instability and mismatch repair deficiency prevalence among Hispanic/Latino individuals with colorectal cancer: a systematic review and meta-analysis.
Synthesis in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
backgroundColorectal cancer (CRC) is the third most common cancer globally, with rising cases in Latin America. MSI-H and MMRd play key roles in CRC, but data on their prevalence in Hispanic/Latino populations are limited. This study evaluates these biomarkers in the region.
methodsA systematic review and meta-analysis were conducted following PRISMA guidelinesin Medline, Virtual Health Library, Scopus, and Web of Science. Random-effects models were used to estimate pooled prevalence due to expected heterogeneity between studies. Studies (cohort and cross-sectional) that evaluated MMRd and/or MSI-H through IHC and PCR techniques in Hispanic/Latino individuals with colorectal cancer (whether sporadic, associated with Lynch Syndrome, or other forms), residing in Latin American countries or elsewhere, were included.
resultsA total of 52 studies including 10,596 patients were included. The pooled prevalence of mismatch repair deficiency (MMRd) and microsatellite instability-high (MSI-H) in Hispanic/Latino populations was 15% (95% CI: 10%-20%; I
conclusionsThis meta-analysis underscores the unique prevalence of MMRd and MSI-H in Hispanics, highlighting regional variations and the need for broader representation.
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