Evidence map›Paper›PMID 42165805›Full record

ArticleMicrobial genomics2026

The effects of bacteriophage cocktail treatment on healthy gut microbiota: an

Teagan L Brown, Duncan Y K Ng, George M Savva, Claire K A Elek, James A D Docherty, Ryan Cook, Rebecca Ansorge, Andrea Telatin, Elizabeth Kutter, Evelien M Adriaenssens

Abstract read
In one paragraph

Article in Microbial genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teagan L BrownQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Duncan Y K NgQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
George M SavvaQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Claire K A ElekQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
James A D DochertyQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Ryan CookQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Rebecca AnsorgeQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Andrea TelatinQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Elizabeth KutterPhagebiotics Research Foundation, Olympia, USA.
Evelien M AdriaenssensQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiome is a complex community that plays an important role in health, where perturbations can result in dysbiosis and disease. Bacteriophages (phages) can provide treatment for bacterial gastrointestinal disease, and commercial preparations such as the Intesti bacteriophage cocktail can be taken orally to target bacterial pathogens. However, interactions between these phages and the native gut microbiota are understudied. To investigate the impact of phage treatment, we used simulated gut models seeded with healthy donor microbiota from three individuals, sequenced the DNA and analysed the bacterial and viral portions from samples obtained over time. Each donor had a unique bacterial composition that diverged with time. When comparing phage-treated to control samples, we observed that

Indexed as

BacteriophagesColonGastrointestinal MicrobiomeBacteriaEscherichia coliHumansPhage Therapybacteriophage cocktailgut microbiotashotgun metagenomicsvirome

Identifiers

PMID42165805
PMCPMC13193621

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.