Evidence map›Paper›PMID 42165785›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Multi-Omics Profiling Reveals Immunomodulatory and Pro-Regenerative Effects of a Graphene Oxide-Collagen Scaffold in Massive Rotator Cuff Tears.

Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Renwen WanDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yechuan DengState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Zixin HuArtificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China.
Yanwei HeDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Xinting FengDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jun MaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yisheng ChenNingde Municipal Hospital, Ningde Normal University, Ningde, Fujian, China.
Zhijie ZhaoDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie MeiThe First Clinical Medicine College, Nanjing Medical University, Nanjing, China.
Zhiheng LinDepartment of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei LuoDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Zhengyuan FangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhufeng HuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Kunlun FengDepartment of Orthopedics, Zhongda Hospital Southeast University, Nanjing, China.
Xinrong LiDepartment of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dan WuDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Bowen HanDepartment of Orthopedics, Zhongda Hospital Southeast University, Nanjing, China.
James Hoi Po HuiDepartment of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Xuanyong LiuState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Chen ChenDepartment of Arthroscopic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Gang ChenDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Shiyi ChenDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Nirong BaoDepartment of Orthopedics, Ward 5, 11th Floor, Surgery Building, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Xuanwu District Nanjing, Jiangsu Province, China.
Jiajun QiuState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Zhiwen LuoDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-0524-9951

Funding

Health Shanghai Initiative Special Fund 2022-02Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica 260009SJ004National Natural Science Foundation of China 82102634Shenzhen "San-Ming" Project of Medicine SZSM202211019Young Elite Scientists Sponsorship Program by CAST 2022-2024QNRC001Zhejiang Clinovation Pride CXTD202502015
6 · The paper itself

Abstract

Massive rotator cuff tears (MRCT) remain a clinical challenge, characterized by poor tendon-bone interface (TBI) healing, severe muscle degeneration, and high postoperative retear rates. Tissue engineering scaffolds offer promising alternatives, yet traditional biomaterials often lack sufficient bioactivity to orchestrate comprehensive tissue regeneration. Herein, we developed a novel graphene oxide (GO)-engineered porcine type I collagen (GO/Col) scaffold and systematically investigated its therapeutic efficacy and underlying molecular mechanisms via multi-omics analyses. Comprehensive characterization showed that GO incorporation improved scaffold stability, wettability, and biocompatibility. In vitro, the GO/Col scaffold enhanced mesenchymal stem cell adhesion and proliferation, promoted osteogenic and chondrogenic differentiation, and suppressed adipogenesis. In a macrophage model system, GO/Col was associated with a shift toward a more reparative, anti-inflammatory phenotype. Using a clinically relevant chronic MRCT rat model, we observed that GO/Col scaffolds significantly improved motor function, biomechanical properties, and tendon-bone regeneration, while inhibiting muscle fibrosis and fatty infiltration. Mechanistically, integrated transcriptomics, proteomics, and mass cytometry analyses revealed GO-mediated modulation of critical signaling pathways involved in immune regulation, stem cell differentiation, and tissue regeneration. Notably, GO activated pro-osteogenic/chondrogenic pathways and anti-inflammatory signatures, while downregulating adipogenic and pro-inflammatory pathways. Collectively, these findings support the potential of GO/Col scaffolds as a bioactive tissue-engineering strategy for chronic MRCT repair.

Indexed as

CollagenGraphiteRegenerationRotator Cuff InjuriesTissue EngineeringTissue ScaffoldsAnimalsMesenchymal Stem CellsMultiomicsRatsSwineCollagengraphene oxideGraphitegraphene oxideimmunomodulationmassive rotator cuff tearmulti‐omicsstem cell differentiationtendon‐bone interface

Identifiers

PMID42165785
PMCPMC13335791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.