ArticleJACC. Advances2026
Gestational Changes in Exercise Capacity in Uncomplicated Singleton Pregnancies.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundPregnancy is associated with well-characterized changes to the cardiopulmonary systems, yet few studies have quantified exercise capacity across trimesters in healthy pregnancies.
objectivesThis study aimed to prospectively assess exercise capacity throughout pregnancy via cardiopulmonary exercise testing (CPET).
methodsHealthy pregnant volunteers underwent ramp-protocol cycle-ergometer CPET in the 1st and 3rd trimesters. Volunteers were followed through delivery to record delivery mode, gestational age at delivery, fetal birth weight, and pregnancy complications. The mean CPET measures were summarized and compared between the 1st and 3rd trimesters with paired t-tests.
resultsA total of 25 pregnant volunteers participated, with a mean age of 31.4 years (SD 3.8). All volunteers had normal baseline echocardiograms (median left ventricular ejection fraction 60%, IQR: 60%-62%). Between the 1st and 3rd trimester, there were no statistically significant differences in the mean peak oxygen consumption (1,804 vs 1,894 mL/min, P = 0.58), mean maximal oxygen uptake at the anaerobic threshold (1,236 vs 1,227 mL/min, P = 0.95), mean O
conclusionsDespite the expected changes in hemoglobin and lung capacity, exercise capacity remained unchanged between the 1st and 3rd trimesters of pregnancy in healthy volunteers.
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