Evidence map›Paper›PMID 42165779›Full record

ArticleJACC. Advances2026

Impact of Female Sex on Survival and Outcomes After Mitral Valve Surgery: A Meta-Analysis.

Xander Jacquemyn, Rohit Ganduboina, Michel Pompeu Sá, Sara J Pereira, Sabine Bleiziffer, Irsa Hasan, Takuya Ogami, Johannes Bonatti, Ibrahim Sultan

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Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xander JacquemynUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rohit GanduboinaDivision of Cardiology, Cedar-Sinai Medical Center, Los Angeles, California, USA.
Michel Pompeu SáDepartment of Cardiovascular Surgery, Heart, Thoracic & Vascular Institute, Cleveland Clinic Florida, Weston, Florida, USA.
Sara J PereiraDivision of Cardiothoracic Surgery, Indiana University Health Methodist Hospital, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sabine BleizifferDepartment of Thoracic and Cardiovascular Surgery, Herz-und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Irsa HasanUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Takuya OgamiUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Johannes BonattiUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ibrahim SultanUPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: issultan@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitral valve disease is a common indication for cardiac surgery, yet long-term, sex-specific outcomes remain incompletely understood.

objectivesThe objective of the study was to evaluate the impact of female sex on survival, reoperation, and recurrent mitral regurgitation (MR) after mitral valve surgery.

methodsWe performed a systematic review and meta-analysis of studies comparing men and women undergoing surgical mitral valve surgery. Time-to-event data were reconstructed and pooled with random-effects models; meta-regression evaluated effect modifiers.

resultsSixteen studies comprising 42,587 patients were included. Women were under-represented, accounting for 39% of the cohort (95% CI: 36%-42%), and were significantly older than men (mean difference: 2.8 years; 95% CI: 1.5-4.0). Women were more than twice as likely to undergo primary mitral valve replacement compared with men (21.9% vs 11.0%; OR: 2.15; 95% CI: 1.62-2.84) and had higher in-hospital mortality than men (OR: 1.38; 95% CI: 1.27-1.50). In unadjusted analyses, female sex was associated with higher all-cause mortality (HR: 1.35; 95% CI: 1.25-1.47) and recurrent MR (HR: 1.57; 95% CI: 1.14-2.15), whereas reoperation rates were similar (HR: 1.35; 95% CI: 0.96-1.89). After adjustment, mortality (HR: 0.96; 95% CI: 0.91-1.01) and reoperation (HR: 1.33; 95% CI: 0.81-2.18) were not significantly different, but recurrent MR remained higher in women (HR: 1.68; 95% CI: 1.13-2.51). Meta-regression revealed higher mitral valve replacement proportion was associated with increased mortality in women.

conclusionsWomen are more likely to undergo mitral valve replacement and have higher recurrent regurgitation, whereas adjusted mortality is similar, suggesting potential benefit of repair-focused strategies when feasible.

Indexed as

cardiac surgerymeta-analysismitral valve diseasemitral valve repairmitral valve replacementsex differences

Identifiers

PMID42165779
PMCPMC13309317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.