Evidence map›Paper›PMID 42165775›Full record

ArticleJACC. Case reports2026

UNICORN TAVR in Native Complex Congenital Aortic Stenosis at High Risk of Coronary Obstruction.

Harish Sharma, William J Chadwick, Russell Franks, James D Newton, Elizabeth Orchard, Sam Dawkins, Thomas J Cahill

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Harish SharmaOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
William J ChadwickOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
Russell FranksOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
James D NewtonOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
Elizabeth OrchardOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
Sam DawkinsOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
Thomas J CahillOxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom. Electronic address: tom.cahill@ouh.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery obstruction is a rare but serious complication of transcatheter aortic valve replacement (TAVR). Undermining iatrogenic coronary obstruction with a radiofrequency needle (UNICORN) is a novel technique of intraleaflet TAVR valve deployment for mitigating this risk. There is limited experience in native aortic valve anatomy, particularly in congenital aortic stenosis. CASE SUMMARY: A 26-year-old man in cardiogenic shock secondary to severe congenital aortic stenosis was successfully treated with emergency TAVR, with leaflet modification using the UNICORN technique due to the high risk of coronary obstruction. DISCUSSION: UNICORN is a novel technique for preventing coronary obstruction in TAVR. Here we describe the first case of UNICORN in congenital aortic stenosis in cardiogenic shock at prohibitive surgical risk. TAKE-HOME MESSAGES: UNICORN can be used successfully in carefully selected native valves at risk of coronary obstruction during TAVR. Use of leaflet modification techniques such as UNICORN enables intervention in a broader cohort of patients unfit for surgery.

Indexed as

aortic valvecongenital heart defectleaflet modificationvalve replacement

Identifiers

PMID42165775
PMCPMC13332682

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.