ArticleJACC. Case reports2026
Persistent Hypoxia After Tricuspid Valve Replacement.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundTranscatheter tricuspid valve replacement (TTVR) is a novel therapy for symptomatic severe tricuspid regurgitation in high-risk surgical patients. Platypnea-orthopnea syndrome has not previously been described as a complication of TTVR. CASE SUMMARY: A 76-year-old woman with symptomatic severe tricuspid regurgitation underwent successful TTVR but developed persistent hypoxia despite negative pulmonary work-up. Her hypoxia followed a platypnea-orthodeoxia pattern. Echocardiography revealed a patent foramen ovale (PFO) with right-to-left shunting. She then underwent successful percutaneous PFO closure, with resolution of her hypoxia. DISCUSSION: Acute post-TTVR anatomic and hemodynamic changes can include right atrial distortion and right ventricular dysfunction in the absence of pulmonary hypertension. These changes may acutely worsen right-sided pressures, leading to right-to-left shunting through an existing PFO. TAKE-HOME MESSAGES: Persistent hypoxia with a platypnea-orthodeoxia pattern immediately after TTVR should prompt thorough work-up including evaluation for PFO. Percutaneous PFO closure can address platypnea-orthodeoxia syndrome in this setting.
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