ArticleJACC. Case reports2026
Late-Presenting Fulminant Immune Checkpoint Inhibitor Myocarditis Managed With Abatacept and Venoarterial Extracorporeal Oxygenation.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmune checkpoint inhibitor (ICI) myocarditis is an uncommon but potentially fatal cardiovascular immune-related adverse event that typically presents early after initiating immunotherapy. CASE SUMMARY: A 36-year-old man with colorectal cancer treated with pembrolizumab presented with cardiogenic shock after 460 days of immunotherapy. Ultimately, he was found to have ICI myocarditis by clinical and histopathological criteria. Despite high-dose corticosteroids, he developed refractory hemodynamic and electrical instability requiring venoarterial extracorporeal membrane oxygenation, abatacept, and therapeutic plasma exchange, with successful recovery of ventricular function and resolution of conduction abnormalities. DISCUSSION: This case illustrates an unusually late, biopsy-confirmed, fulminant presentation of pembrolizumab-associated myocarditis and highlights the importance of maintaining suspicion for immune-related cardiotoxicity even late during immunotherapy. Early recognition and prompt immunosuppression combined with mechanical circulatory support may be lifesaving in such fulminant cases. TAKE-HOME MESSAGE: Early recognition, aggressive immunosuppression, and hemodynamic support are central to the management of ICI myocarditis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.