Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.

Audrey P Gasch

Abstract readReview

In one paragraph

Review in Yeast (Chichester, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.Yeast (Chichester, England) · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Audrey P GaschDepartment of Medical Genetics, Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

Dissecting the influence of genetic background on aneuploidy tolerance in the model eukaryote Saccharomyces cerevisiaeR01GM147271 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2022 to 2025

$1.2M

NIGMS NIH HHS R01 GM147271NIGMS NIH HHS R01GM147271NIH R01GM14975NIH HHS R01GM147271NIH HHS R01GM14975This work was supported by NIH grants R01GM14975 and R01GM147271.

6 · The paper itself

Abstract

All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free-living microbes directly exposed to a changing environment. The environmental stress response (ESR) in Saccharomyces cerevisiae was among the first responses defined at the transcriptome-wide level as a common program triggered by diverse types of stress. Since its original publication over 25 years ago, many studies have explored the role, regulation, and evolution of the ESR and underlying principles of stress defense. This perspective reviews the history of the ESR, recent insights and perspectives into its purpose and regulation, and remaining questions in stress biology primed for the power of yeast experimentation.

Indexed as

Saccharomyces cerevisiaeStress, PhysiologicalGene Expression Regulation, FungalSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiae Proteinsenvironmental stress responseMsn2/Msn4stresstranscriptome

Identifiers

PMID42165638

DOI10.1002/yea.70028

PMCPMC13548943

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.