ArticleMicrobiology spectrum2026
AdamiForge: a modular reverse genetics tool for human adenovirus type 12 (HAdV-A12).
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human adenoviruses (HAdVs) are a large family of viruses comprising more than 100 genotypes distributed across seven species (A to G). Depending on the genotype, they cause respiratory, ocular, urinary tract, or gastrointestinal infections. Despite the considerable diversity within the human adenovirus genus, most of our current knowledge comes from studies on HAdV-C5. The availability of experimental tools, including antibodies and reverse genetics systems, for the study of adenoviruses other than the C5 strain remains very limited. Here, we describe a reverse genetics tool to engineer HAdV-A12, named AdamiForge. HAdV-A12 is phylogenetically distant from HAdV-C5 and differs markedly in its clinical manifestations, warranting the development of dedicated experimental tools. In principle, AdamiForge is similar to the widely used reverse genetics tool for HAdV-C5 known as AdenoBuilder. Briefly, the viral genome is divided into several blocks and cloned into high-copy plasmids. These genomic fragments are released using a restriction enzyme and recombined
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