Evidence map›Paper›PMID 42165525›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Controlling the Guanidinium Cation Rotation by Cation-π Interactions.

Hannah Busch, Lennart Günzel, Ettore Bartalucci, Robert Schuster, Christian Zocher, Martin Börner, Chandan K Das, Florian Taube, Björn Corzilius, Maria Fyta and 3 more

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hannah BuschInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.
Lennart GünzelInstitute of Inorganic Chemistry and Crystallography, Leipzig University, Leipzig, Germany.
Ettore BartalucciInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.
Robert SchusterInstitute of Inorganic Chemistry and Crystallography, Leipzig University, Leipzig, Germany.
Christian ZocherInstitute of Inorganic Chemistry and Crystallography, Leipzig University, Leipzig, Germany.
Martin BörnerInstitute of Inorganic Chemistry and Crystallography, Leipzig University, Leipzig, Germany.
Chandan K DasComputational Biotechnology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0000-4838-8233
Florian TaubeInstitute of Chemistry and Department of Life, Light & Matter, University of Rostock, Rostock, Germany.
Björn CorziliusInstitute of Chemistry and Department of Life, Light & Matter, University of Rostock, Rostock, Germany.
Maria FytaComputational Biotechnology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-5425-7907
Matthias ErnstInstitute For Molecular Physical Sciences, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-9538-6086
Berthold KerstingInstitute of Inorganic Chemistry and Crystallography, Leipzig University, Leipzig, Germany.ORCID https://orcid.org/0000-0001-5386-2809
Thomas WiegandInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0003-3655-6150

Funding

Deutsche Forschungsgemeinschaft 438774970Deutsche Forschungsgemeinschaft 448298270Deutsche Forschungsgemeinschaft 455238107Deutsche Forschungsgemeinschaft 455240421Deutsche Forschungsgemeinschaft TRR-386Federal Ministry of Research, Technology, and Space 02NUK077CNHR Center NHR4CES at RWTH Aachen University p0022407
6 · The paper itself

Abstract

Guanidinium plays an essential role in many disciplines of biology and chemistry, particularly due to its unique role of being engaged in a variety of molecular-recognition events that are facilitated by the ability to participate in a broad range of noncovalent interactions. Guanidinium cations in salts or perovskite materials are known to rotate along their local symmetry axes rather fast in the order of ps, even in the solid state. We herein employ a π-container to trap a guanidinium cation inside the aromatic cavity by cation-π interactions. X-ray crystallography and solid-state nuclear magnetic resonance (NMR) spectroscopy at fast magic-angle spinning (MAS) frequencies have been utilized to probe the underlying host-guest interactions. The guanidinium motion has been fully characterized by temperature-dependent MAS-NMR experiments down to 100 K, as well as by a variety of further solid-state NMR experiments, and supplemented by quantum-chemical calculations and molecular dynamics (MD) simulations. Our data point to a restriction of the guanidinium cation rotation about the local C

Indexed as

cation–π interactiondynamicsfast magic‐angle spinningguanidiniumsolid‐state NMR

Identifiers

PMID42165525
PMCPMC13360552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.