ArticleJACC. Case reports2026
Epicardial Substrate Ablation in Gene-Negative Brugada Syndrome: U.S. Experience and Mechanistic Insights.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ventricular Arrhythmias: Mechanisms, Mimics, and Ablation.JACC. Case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpicardial ablation for Brugada syndrome targeting abnormal right ventricular outflow tract (RVOT) substrate with local abnormal ventricular activity (LAVA) demonstrated efficacy in European trials but remains uncommon in the United States. CASE SUMMARY: A 51-year-old man with type II Brugada pattern, febrile syncope, inducible ventricular fibrillation, and negative genetic testing declined implantable cardiac-defibrillator implantation. Electroanatomic mapping revealed local abnormal ventricular activation in the RVOT epicardium. Procainamide provoked type I Brugada pattern and prolongation of local RVOT activation. Radiofrequency ablation eliminated LAVA and normalized the electrocardiogram. DISCUSSION: Dynamic correlation of accentuated LAVA with procainamide provocation of type I Brugada pattern implicates delayed depolarization as the mechanism for pseudo-ST-segment changes in Brugada syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.