Evidence map›Paper›PMID 42165478›Full record

ArticleJACC. Case reports2026

PR Interval Alternans and the Mystery of Inverse Decremental Conduction.

Alyssa Zakala, Mohammed Hussein Kamareddine, Farah Olleik, Ali Keramati, Gan-Xin Yan

Abstract read
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa ZakalaLankenau Medical Center, Main Line Health, Wynnewood, Pennsylvania, USA.
Mohammed Hussein KamareddineLankenau Medical Center, Main Line Health, Wynnewood, Pennsylvania, USA.
Farah OlleikLankenau Medical Center, Main Line Health, Wynnewood, Pennsylvania, USA.
Ali KeramatiLankenau Medical Center, Main Line Health, Wynnewood, Pennsylvania, USA; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA. Electronic address: KeramatiA@mlhs.org.
Gan-Xin YanLankenau Medical Center, Main Line Health, Wynnewood, Pennsylvania, USA; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA; Fuwai Huazhong Hospital, Zhengzhou, Henan, China; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address: yang@mlhs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

case summaryA 73-year-old man with severe aortic stenosis and preexisting right bundle branch block (RBBB) underwent transcatheter aortic valve replacement. Postprocedural day 4 mobile cardiac outpatient telemetry revealed intermittent atrioventricular block. A 12-lead electrocardiogram obtained in the emergency department revealed PR interval alternans with RBBB, with longer PR following longer preceding RP intervals, and shorter PR following shorter RP intervals. He suddenly experienced cardiac arrest due to proximal atrioventricular block, requiring cardiopulmonary resuscitation. TAKE-HOME MESSAGES: Inverse decremental conduction, known as Yan conduction, demonstrates an inverse relationship between conduction time and frequency of upstream stimulation. Inverse decremental conduction within the left bundle branch in the setting of RBBB may manifest as PR alternans, heralding proximal atrioventricular block.

Indexed as

inverse decremental conductionleft bundle branch blockparoxysmal AV blockright bundle branch blockYan conduction

Identifiers

PMID42165478
PMCPMC13198130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.