ECG-Facilitated Detection of Light Chain Cardiac Amyloidosis in Long-Standing MGUS.

Jakub Piwowarski, Gina Barzen, Stephan Bohl, Katrin Hahn, Sebastian Spethmann

Abstract read

In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jakub PiwowarskiDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Charité Mitte, Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Charité Mitte, Berlin, Germany; Amyloidosis Center Charité Berlin (ACCB), Amyloidosis Center of Charité, Campus Charité Mitte, Campus Benjamin Franklin, and Campus Virchow Klinikum, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

Gina BarzenDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Charité Mitte, Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Charité Mitte, Berlin, Germany; Amyloidosis Center Charité Berlin (ACCB), Amyloidosis Center of Charité, Campus Charité Mitte, Campus Benjamin Franklin, and Campus Virchow Klinikum, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

Stephan BohlAmyloidosis Center Charité Berlin (ACCB), Amyloidosis Center of Charité, Campus Charité Mitte, Campus Benjamin Franklin, and Campus Virchow Klinikum, Berlin, Germany; Department of Hematology, Oncology and Cancer Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.

Katrin HahnAmyloidosis Center Charité Berlin (ACCB), Amyloidosis Center of Charité, Campus Charité Mitte, Campus Benjamin Franklin, and Campus Virchow Klinikum, Berlin, Germany; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.

Sebastian SpethmannDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Charité Mitte, Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Charité Mitte, Berlin, Germany; Amyloidosis Center Charité Berlin (ACCB), Amyloidosis Center of Charité, Campus Charité Mitte, Campus Benjamin Franklin, and Campus Virchow Klinikum, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. Electronic address: sebastian.spethmann@dhzc-charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 76-year-old outpatient with light-chain monoclonal gammopathy of undetermined significance presented for evaluation of new-onset, nonspecific symptoms. Paraproteinemia remained stable for over 25 years without prior signs of organ manifestation. Physical examination was unremarkable. To complete routine diagnostics, a 12-lead electrocardiogram was performed, demonstrating features suggestive of amyloidosis, including low QRS voltages and an unexplained anterior pseudoinfarction pattern. It contributed to initiating further evaluation, leading to the diagnosis of light-chain cardiac amyloidosis. TAKE-HOME MESSAGE: This case highlights the potential of electrocardiography as an easily accessible tool for increasing suspicion of cardiac complications in long-standing monoclonal gammopathy of undetermined significance, even in clinically inconclusive cases.

Indexed as

cardiac riskelectrocardiogramrisk factorsecondary prevention

Identifiers

PMID42165464

DOI10.1016/j.jaccas.2026.107622

PMCPMC13198135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.