Evidence map›Paper›PMID 42165460›Full record

ArticleJACC. Case reports2026

Propafenone Toxicity Presenting With Wide QRS and Transient Ventricular Dyskinesia.

Larissa Araújo de Lucena, Flávia da Costa Fernandes Mesquita, Micheli Rigon Madeira, Ferdinand Gilbert Saraiva da Silva Maia

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Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Larissa Araújo de LucenaHospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: larissa.js@hotmail.com.
Flávia da Costa Fernandes MesquitaHospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Micheli Rigon MadeiraHospital Promater, Natal, Rio Grande do Norte, Brazil.
Ferdinand Gilbert Saraiva da Silva MaiaHospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPropafenone, a class Ic antiarrhythmic with a narrow therapeutic window, may cause conduction disturbances. CASE SUMMARY: A 68-year-old man on propafenone presented with dyspnea and dizziness. Electrocardiogram showed QRS widening (160 milliseconds). Angiography excluded occlusion but showed transient ventricular dysfunction. Sodium bicarbonate normalized QRS complex and reversed dysfunction.

conclusionsNew wide-QRS rhythm in patients on class Ic agents suggests sodium channel blocker toxicity. QRS narrowing after bicarbonate is diagnostically important. Early treatment ensures reversibility and prevents arrhythmias. TAKE-HOME MESSAGES: Toxicity in new wide-QRS rhythm on class Ic drugs should be assumed. QRS narrowing after bicarbonate is key. Early treatment prevents fatal complications.

Indexed as

antiarrhythmic drugsdrug toxicityelectrocardiographypropafenone

Identifiers

PMID42165460
PMCPMC13198115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.