Brugada Phenocopy Associated With the Tyrosine Kinase Inhibitor Avapritinib During Febrile Illness.

Obaid I Haque, Obaid Ur Rehman, Leen Othman, Mansoor Mozayan, Konstantinos N Aronis

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Obaid I HaqueInternal Medicine, MedStar Health Georgetown University, Baltimore, Maryland, USA. Electronic address: Obaid.I.Haque2@medstar.net.

Obaid Ur RehmanInternal Medicine, MedStar Health Georgetown University, Baltimore, Maryland, USA.

Leen OthmanInternal Medicine, MedStar Health Georgetown University, Baltimore, Maryland, USA.

Mansoor MozayanCardiology at MedStar Franklin Square Medical Center, Baltimore, Maryland, USA.

Konstantinos N AronisDivision of Cardiology, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrugada phenocopy is a reversible Brugada pattern on an electrocardiogram (ECG) caused by identifiable clinical conditions (such as fever, electrolyte abnormalities, or drug exposure) in patients without true congenital Brugada syndrome, which is an inherited arrhythmogenic disorder often associated with SCN5A mutations. CASE SUMMARY: A 53-year-old man with metastatic myeloid sarcoma presented with high-grade fever and chest pain. He was previously treated with imatinib, discontinued because of severe skin rash, followed by dasatinib, and most recently avapritinib, initiated 3 weeks before presentation. The initial 12-lead ECG demonstrated a spontaneous type 1 Brugada pattern in leads V DISCUSSION: We report a case of type 1 Brugada ECG pattern unmasked by febrile illness after avapritinib initiation, with an incidental finding of heterozygous missense variant in the JPH2 gene. TAKE-HOME MESSAGE: This case introduces a previously unrecognized association between avapritinib and Brugada pattern and suggests avapritinib as a potential pharmacologic trigger in susceptible individuals.

Indexed as

avapritinibBrugada patternBrugada syndromecase reportchannelopathytyrosine kinase inhibitor

Identifiers

PMID42165456

DOI10.1016/j.jaccas.2026.107364

PMCPMC13198151

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