Evidence map›Paper›PMID 42165438›Full record

ArticleACS chemical neuroscience2026

Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells.

Kazi Asraful Alam, Josep Martí-Solans, Dorothea Schall, Sumit Kumar, Shahid Muhammad Iqbal, Knut Teigen, Simone Berkel, Daniela Mauceri, Bengt Erik Haug, Sara I Liin and 3 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazi Asraful AlamDepartment of Biomedicine, University of Bergen, Bergen 5007, Norway.ORCID 0000-0001-5498-6977
Josep Martí-SolansMichael Sars Centre, University of Bergen, Bergen 5006, Norway.
Dorothea SchallInstitute of Human Genetics, Heidelberg University, Heidelberg 69120, Germany.
Sumit KumarDepartment of Biomedicine, University of Bergen, Bergen 5007, Norway.ORCID 0000-0002-4588-7237
Shahid Muhammad IqbalMichael Sars Centre, University of Bergen, Bergen 5006, Norway.
Knut TeigenDepartment of Biomedicine, University of Bergen, Bergen 5007, Norway.
Simone BerkelInstitute of Human Genetics, Heidelberg University, Heidelberg 69120, Germany.
Daniela MauceriDepartment of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg 69120, Germany.ORCID 0000-0003-1225-4633
Bengt Erik HaugDepartment of Chemistry, University of Bergen, Bergen 5007, Norway.ORCID 0000-0003-3014-9538
Sara I LiinDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping 58185, Sweden.
Timothy LynaghMichael Sars Centre, University of Bergen, Bergen 5006, Norway.ORCID 0000-0003-4888-4098
Aurora MartinezDepartment of Biomedicine, University of Bergen, Bergen 5007, Norway.
Jan HaavikDepartment of Biomedicine, University of Bergen, Bergen 5007, Norway.ORCID 0000-0001-7865-2808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current (

Indexed as

KCNQ1 Potassium ChannelNeural Stem CellsPotassium Channel BlockersAnimalsHumansMolecular Docking SimulationPotassium Channels, Voltage-GatedXenopus laevisKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassium Channel BlockersPotassium Channels, Voltage-Gatedarrhythmiabenzodiazepinesdrug discoveryion channelsKCNQ1/KCNE1neurite growthvirtual screening

Identifiers

PMID42165438
PMCPMC13237734

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.