Evidence map›Paper›PMID 42165375›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Architected Inverse Nacre Hydrogels With High Strength and Crack-Insensitive Toughness.

Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao and 1 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haidi WuSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Qin SuSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Cheng GuanSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Biwang PanSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Wenjie HuSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Jun YanSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Yifan FengSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Longcheng TangKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China.
Xuewu HuangSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.
Jiefeng GaoSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.ORCID https://orcid.org/0000-0002-6038-9770
Wancheng GuSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, China.

Funding

China Postdoctoral Science Foundation 2016M600446High-end Talent Project of Yangzhou UniversityJiangsu Province Postdoctoral Science Foundation 1601024ANational Natural Science Foundation of China 51873178National Natural Science Foundation of China 52473049National Natural Science Foundation of China 52501120Natural Science Foundation of Jiangsu Province BK20240934Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX25_3931Qing Lan Project of Yangzhou University and Jiangsu ProvinceResearch Start-Up Funds of Yangzhou University
6 · The paper itself

Abstract

The practical deployment of synthetic hydrogels in load-bearing applications has long been hindered by their intrinsically low fracture toughness, poor fatigue resistance, and the persistent strength-toughness trade-off. Here, we propose an "inverse nacre" design principle that fundamentally overcomes these limitations by integrating hierarchical alignment of poly(vinyl alcohol) (PVA) chains and MXene nanosheets via a scalable thermo-calendering process. In this inverted structure, a minimal quantity of aligned MXene nanosheets serves as continuous, high-stiffness "bricks", while the PVA hydrogel forms a ductile, energy-dissipating "mortar". This inversion introduces a dual-function reinforcement mechanism: MXene nanosheets impart stiffness, crack-bridging, and deflection capabilities, while simultaneously suppressing PVA crystallization, thereby promoting molecular alignment and enhancing deformability. The resulting cooperative architecture achieves an exceptional combination of tensile strength (63.48 MPa), work of fracture (54.79 MJ/m

Indexed as

mechanical propertiesMXeneorientationPVA hydrogels

Identifiers

PMID42165375
PMCPMC13335519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.