ArticleJournal of pediatric gastroenterology and nutrition2026
Efficacy and safety of post-Kasai steroid-based protocol in biliary atresia.
Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06447051 (Efficacy of New Post Kasai ILBS Protocol in BiliaryAtresia.), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Efficacy of New Post Kasai ILBS Protocol in BiliaryAtresia.
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7 authors.
Funding
Abstract
objectivesThis study aims to assess whether steroid-based regimen enhances the clearance of jaundice and improves native liver survival (NLS).
methodsWe included all infants with biliary atresia (BA) undergoing Kasai portoenterostomy (KPE) at our centre. The algorithm-initiated prednisolone was initiated if stools remained acholic.
resultsOf 127 infants, 70 formed the steroid group (SG) and 57 the historical cohort (HC). Jaundice clearance at 6 months was superior with steroids (61.4% vs. 38.6%; odds ratio [OR] 2.53, 95% confidence interval [CI] 1.23-5.19, p = 0.013). Kaplan-Meier analysis demonstrated improved 24-month NLS (log-rank p = 0.044) in SG. Multivariate analysis identified younger age at KPE (adjusted odds ratio [aOR] 1.021 per day, 95% CI 1.004-1.038, p = 0.016), lower pre-operative bilirubin (aOR 1.163, 95% CI 1.024-1.320, p = 0.020) and steroid use (aOR 2.13, 95% CI 1.001-4.53, p = 0.050) as independent predictors of success.
conclusionsModerate-dose prednisolone after KPE enhances early bile drainage and prolongs native liver survival. Optimal benefit is achieved when surgery is performed at ≤70 days of age.
trial registrationClinicalTrials.gov identifier: NCT06447051 (Clinicaltrials.gov) https://clinicaltrials.gov/study/NCT06447051.
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