Evidence map›Paper›PMID 42165104›Full record

ReviewEssays in biochemistry2026

Colony politics to chemical warfare: phenotypic plasticity in Streptomyces.

John T Munnoch, Paul A Hoskisson

Abstract readReview
In one paragraph

Review in Essays in biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John T MunnochStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, U.K.
Paul A HoskissonStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, U.K.ORCID 0000-0003-4332-1640

Funding

Leverhulme Trust (The Leverhulme Trust) RPG-2022-316, RPG-2023-128Royal Academy of Engineering (RAENG) RCSRF2021\11\15UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/T001038/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/Y00082X/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) NPRONET POC045
6 · The paper itself

Abstract

Members of the genus Streptomyces are prolific producers of antibiotics and bioactive natural products, whose biosynthesis is intricately linked to complex social and ecological interactions. Understanding how these bacteria adaptively regulate development and natural product biosynthesis in response to diverse environmental cues remains incomplete. Here, recent advances are synthesised revealing that phenotypic plasticity in Streptomyces is underpinned by regulatory networks integrating physiological and social signals, enabling multicellular differentiation, division of labour, and alternative growth modes such as exploration and foraging. These dynamic responses allow colonies to balance competition, cooperation, and reproduction in fluctuating environments. Our insights highlight the ecological and evolutionary significance of plasticity in shaping Streptomyces biology, with implications for natural product discovery and understanding microbial community dynamics.

Indexed as

StreptomycesAdaptation, PhysiologicalAnti-Bacterial AgentsBiological ProductsPhenotypeAnti-Bacterial AgentsBiological Productsantibioticsdevelopmentnatural productsplasticitysporulationStreptomyces

Identifiers

PMID42165104
PMCPMC13538131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.