Evidence map›Paper›PMID 42165096›Full record

SynthesisPsychological medicine2026

Altered amygdala resting-state functional connectivity in anxiety disorders: a coordinate-based meta-analysis.

Lu Lu, Haoran Xu, Rui Wang, Baoshuai Zhang, Baolin Wu, Lisha Zhang, Xiao Li, Qiyong Gong, Jeffrey R Strawn

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lu LuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Haoran XuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-3362-1685
Rui WangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Baoshuai ZhangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-5580-9961
Baolin WuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-4574-9747
Lisha ZhangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xiao LiDepartment of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Qiyong GongDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-5912-4871
Jeffrey R StrawnDepartment of Psychiatry and Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Funding

National Natural Science Foundation of China 82202116
6 · The paper itself

Abstract

backgroundAnxiety disorders are associated with disrupted amygdala connectivity; however, resting-state functional MRI studies have reported heterogeneous findings. To clarify these inconsistencies, we conducted a meta-analysis of amygdala-based connectivity studies.

methodsA systematic search of Embase, PubMed, and Web of Science was performed through December 26, 2025. Studies comparing amygdala-based whole-brain resting-state functional connectivity in patients with anxiety disorders versus healthy controls were included. Meta-analysis was conducted with the latest software - Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), which employs voxel-wise tests and multiple corrections to minimize false positives. Subgroup analyses were performed to examine differences by age and hemisphere.

resultsFifteen datasets (378 patients, 405 controls) were included. Compared to healthy controls, patients with anxiety disorders had decreased amygdala-anterior cingulate cortex (ACC,

conclusionsReduced connectivity between the left amygdala and the ipsilateral ACC was the most robust neuroimaging marker of anxiety disorders, which suggests a lateralized vulnerability. By applying updated analytic methods, this study refines our understanding of the neuropathology of anxiety disorders and provides a potential primary target for biomarker development and novel interventions.

Indexed as

AmygdalaAnxiety DisordersConnectomeHumansMagnetic Resonance ImagingACCamygdalaanxiety disordermeta-analysisresting-state functional connectivity

Identifiers

PMID42165096
PMCPMC13200151

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