ArticleNeuroimage. Reports2026
3D quantitative MRI for cognitive performance: T1 relaxation times of the right putamen and volumes of the left hippocampus as key biomarkers.
Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mild cognitive impairment (MCI) represents anearly stage of cognitive decline, often preceding dementia. While hippocampal atrophy is a recognized imaging marker, the role of deep gray matter structures and tissue alterations remains less understood. This study aimed to assess whether quantitative T1 (qT1) relaxometry and volumetric measures derived from synthetic MRI are associated with global cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA). Methods: In this cross-sectional study, 74 healthy adults (mean age 43.7 years, 50% female) underwent 3D-synthetic MRI and MoCA testing. Participants were stratified into cognitively normal (MoCA ≥26) and MCI (MoCA <26) groups. Brain volumes and qT1 values were extracted across regions. Associations with MoCA were assessed using multivariate regression, controlling for demographic and clinical covariates. Results: Left hippocampal volume was significantly reduced in the MCI group (p = 0.019) and was positively associated with MoCA scores (R Conclusions: Hippocampal volume and putamen qT1 are independent imaging correlates of cognitive performance. qT1 mapping may detect early subtle tissue changes not captured by conventional volumetry, supporting its potential role as a biomarker in cognitive aging.
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