Evidence map›Paper›PMID 42165022›Full record

ArticleFrontiers in endocrinology2026

PI4-kinase A is essential for survival of the GnRH neurons.

Stephanie Constantin, Naseratun Nessa, Stanko S Stojilkovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie ConstantinSection on Cellular Signaling, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Naseratun NessaSection on Cellular Signaling, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Stanko S StojilkovicSection on Cellular Signaling, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The signaling pathways that control embryonic development and migration of gonadotropin-releasing hormone (GnRH) neurons, as well as the postnatal fate and function of differentiated cells, are the subject of ongoing research. Here, we examined the role of phosphoinositides in this complex multistep process by generating GnRH neuron-specific phosphatidylinositol 4-kinase alpha knockout mice. The knockout mice were indistinguishable from their control littermates at all time points studied. However, adult knockout females and males were infertile, as reflected by the absence of GnRH immunoreactivity and

Indexed as

Gonadotropin-Releasing HormoneNeuronsAnimalsCell SurvivalFemaleHypothalamusKisspeptinsMaleMiceMice, KnockoutNeurogenesisGonadotropin-Releasing HormoneKisspeptinsdevelopmentGnRH neuronskisspeptin neuronsneuronal survivalphosphatidylinositol 4-kinase alphaPI(3, 4, 5)P3PI(4,5)P2PI4P

Identifiers

PMID42165022
PMCPMC13183541

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.