Evidence map›Paper›PMID 42164996›Full record

ReviewBioactive materials2026

Current and emerging antibacterial strategies for periprosthetic joint infection: An overview.

Marco Fosca, Veronica Manescu, Iulian Antoniac, Julietta V Rau

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marco FoscaIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133, Rome, Italy.
Veronica ManescuFaculty of Material Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, District 6, RO-060042, Bucharest, Romania.
Iulian AntoniacFaculty of Material Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, District 6, RO-060042, Bucharest, Romania.
Julietta V RauIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periprosthetic Joint Infection (PJI) represents one of the most serious complications following joint arthroplasty, with impactful consequences in the clinic and economy. Characterized by biofilm formation on implant surfaces, PJI poses significant therapeutic challenges due to the limited efficacy of systemic antibiotics and the increasing prevalence of multidrug-resistant bacteria. This review paper presents a comprehensive analysis of current and emerging antibacterial strategies designed to mitigate the risk of infection in total joint arthroplasty (TJA). It spans two decades of literature, from 2003 to 2025, with a particular focus on local antibiotic delivery systems, including bone cements, spacers, beads, and novel biomaterial carriers evaluated across

Indexed as

Antibacterial bone cementsInnovative solutionsIn vitro assaysIn vivo modelsPeriprosthetic joint infection

Identifiers

PMID42164996
PMCPMC13185784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.