Evidence map›Paper›PMID 42164978›Full record

ArticleThe application of clinical genetics2026

Genetic Polymorphisms of Transforming Growth Factor Receptors (TGF-βRI, TGF-βRII) and Risk Factors Associated with Keloid Scars in Burkina Faso: A Cross-Sectional Study.

Koffi Agbessi Keto, Danielle Belemsigri, Serge Theophile Soubeiga, Marcelin Bonkoungou, Hadiaratou Nafore Badiala Gadiaga, Bibata Compaore, Pegdwinde Abel Sorgho, Albert Theophane Yonli, Wendkuuni Florencia Djigma, Jacques Simpore and 1 more

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Article in The application of clinical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Koffi Agbessi KetoDepartment of Biochemistry-Microbiology, Laboratory of Molecular Biology and Molecular Genetics, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso.ORCID 0009-0006-0894-6097
Danielle BelemsigriDepartment of Dermatology and Venereology, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso.ORCID 0009-0003-9785-0975
Serge Theophile SoubeigaDepartment of Biomedical and Public Health, Research Institute for Health Sciences, Ouagadougou, Burkina Faso.ORCID 0000-0002-9741-2428
Marcelin BonkoungouDepartment of Dermatology and Venereology, Bogodogo University Hospital, Ouagadougou, Burkina Faso.
Hadiaratou Nafore Badiala GadiagaDepartment of Dermatology and Venereology, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso.ORCID 0009-0008-9099-8201
Bibata CompaoreDepartment of Dermatology and Venereology, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso.ORCID 0009-0007-1365-1485
Pegdwinde Abel SorghoDepartment of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.ORCID 0000-0002-8814-4433
Albert Theophane YonliDepartment of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso.ORCID 0000-0003-0471-5057
Wendkuuni Florencia DjigmaDepartment of Biochemistry-Microbiology, Laboratory of Molecular Biology and Molecular Genetics, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso.ORCID 0000-0002-6895-6725
Jacques SimporeDepartment of Biochemistry-Microbiology, Laboratory of Molecular Biology and Molecular Genetics, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso.ORCID 0000-0002-0415-9161
Pascal NiambaDepartment of Dermatology and Venereology, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The keloids scar is a skin scarring pathology with a higher frequency in the black population. Several genetic polymorphisms, including those of transforming growth factor receptors, have been identified as probable susceptibility genes. This study aimed to characterize the polymorphisms of Methods: This was a cross-sectional study that included 141 subjects with keloids and conducted from April 2021 to April 2022. Genomic DNA was extracted using the "PureLink Results: The average age of the study population was 34 ± 15 years and O Rhesus positive blood group (O+) was predominant (36.88%). All subjects (100%) were heterozygous (TG) for rs121918710. Medical or surgical history, family history, blood type, and rs28934568 polymorphism were related to the number of sites of keloids on the body. Patients with a medical history (9.8%) were carriers of the mutant allele C for rs28934568. Mossi ethnic had more than 8 times risk of developing a keloid scar (p=0.030; OR=8.66 (95% CI: 1.230-60.902). Conclusion: The presence in all the patients of the mutated allele for the

Indexed as

allelesBurkina Fasokeloidspolymorphismstransforming growth factors

Identifiers

PMID42164978
PMCPMC13185948

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