Evidence map›Paper›PMID 42164888›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Effects of Antibiotic-Induced Gut Microbiota Dysbiosis on Arsenic Bioaccumulation and Transformation in Mice and Its Potential Mechanisms.

Xiyan Jiang, Fang Zhao, Rui Li, Shimao Xiong, Peng Xiao, Pengfei Wang, Huimin Gao, Yue Wu, Kang Xiao, Xiaolin Cai and 3 more

Abstract read
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiyan JiangCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Fang ZhaoCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Rui LiCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Shimao XiongCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Peng XiaoCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Pengfei WangFaculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, Yunnan China.
Huimin GaoCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.
Yue WuSino-Danish Centre for Education and Research, University of Chinese Academy of Sciences, Beijing 101408, China.
Kang XiaoBeijing Yanshan Earth Critical Zone National Research Station, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID https://orcid.org/0000-0001-6475-1960
Xiaolin CaiCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID https://orcid.org/0000-0002-1775-6547
Naiyi YinCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID https://orcid.org/0000-0002-2901-1438
Guoxin SunResearch Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0002-9397-3164
Yanshan CuiCollege of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID https://orcid.org/0000-0002-7805-1567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota plays a crucial role in arsenic (As) metabolism, yet the extent of As metabolism under gut dysbiosis and the gut's response to As exposure remain lacking. This study used a mouse model with gut dysbiosis induced by cefoperazone to explore As bioaccumulation, transformation, and excretion. By integrating absolute quantification methods, this study monitored the responses of gut microbiota, As biotransformation genes (ABGs), and gut metabolites in mice exposed to 1 and 10 mg/L As. Arsenic accumulation in the liver, spleen, heart, ileum, and blood was markedly decreased in gut dysbiosis mice exposed to 10 mg/L As. These mice also exhibited lower proportions of DMA-(V) and As-(V) in the liver compared with normal mice. A total of 17 ABGs were detected in the mouse gut, with a significant reduction in their absolute abundance in gut dysbiosis mice (e.g.,

Indexed as

absolute quantificationarsenic biotransformation genesarsenic metabolismgut microbiota disruptionmetabonomics

Identifiers

PMID42164888
PMCPMC13185062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.