ReviewEnvironment & health (Washington, D.C.)2026
AHR: The Overlooked Mediator in SkincareBridging Environmental Sensing and Skin Physiology.
Review in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aryl hydrocarbon receptor (AHR) has expanded beyond its classical role and is increasingly recognized for its involvement in mediating the biological effects of cosmetic bioactives. Increasing evidence indicates that key cosmetic compounds, including resveratrol, ferulic acid, and curcumin, exert part of their effects through AHR activation, rather than solely via classical nuclear factor erythroid 2related factor 2 (NRF2) and nuclear factor kappa B (NF-κB)mediated pathways. Based on a comprehensive review of existing studies, AHR regulates multiple pathways relevant to skin function, including collagen synthesis, melanogenesis, barrier integrity, and metabolic signaling, highlighting its role as an integrative hub coordinating complex skin responses. This review frames AHR not merely as a xenobiotic sensor but as a transcription factor integrating multiple signals from environmental and bioactive inputs. Finally, we discuss how emerging tools, including AI-driven modeling and synthetic biology, may expand opportunities for future AHR-focused research and help inform more tailored skincare strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.