ReviewEnvironment & health (Washington, D.C.)2026
From Target-Nontarget to Nontarget Screening: A Review on Screening Methods for Organic Pollutants Based on High-Resolution Mass Spectrometry.
Review in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From laboratory to field: a critical review of multi-modal sensing frameworks for emerging contaminant monitoring.Mikrochimica acta · 2026Review
- Non-Targeted Hyperspectral Imaging Screening of Adulterants and Congeneric Species inFoods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although certain substances exist in the environment at trace concentrations, their ecological risks remain significant, making nontarget screening (NTS) one of the most important topics in the fields of environmental and analytical chemistry today. In recent years, with the development of high-resolution mass spectrometry (HRMS), the higher precision and accuracy have provided mass spectrometry (MS) characteristics with deeper application significance, offering new perspectives for NTS. This review briefly introduces the principles and methodologies of different MS characteristics and summarizes emerging advancements in screening strategies based on these characteristics. We innovatively propose a target-nontarget to nontarget screening workflow, which links different MS characteristics to achieve comprehensive NTS. This workflow prioritizes the currently applied MS characteristics, aiming to integrate various analytical steps to expand the screening coverage while maintaining reliability. The prioritization includes 1) mass defect (MD) analysis, 2) isotope patterns, 3) characteristic fragments, 4) construction of MS characteristics through chemical reactions, and 5) intermolecular connectivity MS characteristics mining. Subsequently, we provided an overview of the mining and prediction of MS characteristics based on machine learning. Finally, we evaluated the challenges of transitioning from target-nontarget to nontarget workflows and proposed future perspectives for NTS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.