ArticleiScience2026
Tumor microenvironment responsive copper-doped carbon dots for synergistic chemotherapy and cuproptosis in laryngeal cancer.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Tannic Acid-Copper Coordination Gel-Coated Mesoporous Cuprous Oxide Nanoplatform for Synergistic 5-FU Chemotherapy and Enhanced Chemodynamic Therapy.Gels (Basel, Switzerland) · 2026Article
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10 authors.
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Abstract
Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis because it is often diagnosed late, and chemotherapy causes substantial side effects. To improve efficacy and reduce toxicity, we developed a tumor microenvironment-responsive nanoplatform, 5-fluorouracil-loaded copper-doped carbon dots (5-Fu@CuCDs). The nanocomposite was synthesized by a one-step hydrothermal method, showed a uniform spherical morphology of about 15.7 nm, and achieved a drug loading rate of about 30%. Structural analyses confirmed successful copper doping and stable drug incorporation. Under weakly acidic tumor microenvironment conditions, the nanoplatform catalyzed hydroxyl radical generation from hydrogen peroxide and depleted intracellular glutathione, thereby enhancing oxidative stress. Density functional theory calculations further supported its high peroxidase-like catalytic activity.
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