Evidence map›Paper›PMID 42164854›Full record

ArticleiScience2026

The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis.

Hirotaka Ariyama, Atsushi Tsukamura, Satoko Miyatake, Satoko Okado, Itsuki Itabashi, Ami Ogura, Atsunobu Suzuki, Hyuga Kurakawa, Yuki Sakaguchi, Yuhki Nakatake and 36 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Hirotaka AriyamaDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Atsushi TsukamuraDepartment of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
Satoko MiyatakeDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Satoko OkadoDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Itsuki ItabashiDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Ami OguraDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Atsunobu SuzukiDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Hyuga KurakawaDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Yuki SakaguchiDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.
Yuhki NakatakeDepartment of Reproductive Medicine, Center for Regenerative Medicine, National Center for Child Health and Development (NCCHD), Tokyo, Japan.
Ryunosuke SanadaDepartment of Reproductive Medicine, Center for Regenerative Medicine, National Center for Child Health and Development (NCCHD), Tokyo, Japan.
Ichiro TerakadoResearch Center for Animal Life Science (RCALS), Shiga University of Medical Science, Otsu, Japan.
Eriko KoshimizuDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Takeshi MizuguchiDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Keisuke HamadaDepartment of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kazuhiro OgataDepartment of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Eiji NakagawaDepartment of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takafumi SakakibaraDepartment of Pediatrics, Nara Medical University, Kashihara, Japan.
Manabu ShiraiOmics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan.
Yoshitaka FujiharaDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Osaka, Japan.
Mukhtar UllahInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Mathieu QuinodozInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Carlo RivoltaInstitute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.
Abdul Ghafoor KhanBannu Medical College, MTI Bannu, Bannu, Pakistan.
Muhammad Nadeem KhanBannu Medical College, MTI Bannu, Bannu, Pakistan.
Muhammad AnsarDepartment of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland.
Erica H GerkesUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Nijmegen, the Netherlands.
Tuula RinneDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
Alexander P A StegmannDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
Margje SinnemaDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
Malak Ali AlghamdiMedical Genetics Division, Pediatric Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Essa AlharbyCenter for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Reham M BalahmarCenter for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Naif A M AlmontashiriCenter for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Sarah BaerInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Amélie PitonLaboratoire de Diagnostic Génétique, Institut de Génétique Médicale d'Alsace (IGMA), Hôspitaux Universitaire de Strasbourg, Strasbourg, France.
Carla Díes CuriàIMPaCT-Genómica - Enfermedades Raras, Servei de Genètica, Hospital del Mar, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Sandra MercierService de génétique médicale, CHU de Nantes, Nantes, France.
Benjamin CognéService de génétique médicale, CHU de Nantes, Nantes, France.
Patrick YapGenetic Health Service New Zealand (Northern Hub), Auckland City Hospital, University of Auckland, Auckland, New Zealand.
Shin-Ya MoritaDepartment of Pharmacotherapeutics, Shiga University of Medical Science, Otsu, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Mitsuhiro KatoDepartment of Pediatrics, Showa Medical University, Tokyo, Japan.
Yoshihiro MaruoDepartment of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
Naomichi MatsumotoDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaki MoriDepartment of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms regulating the phospholipid (PL) metabolism in the nucleus remain to be elucidated. Here, we describe the role of Dop1a in controlling PL abundance in nuclear membranes (NMs) under the control of mTOR signaling. A shortage of lysophosphatidic acid (LPA) triggers the rapid localization of Dop1a to the nuclear pore complexes (NPCs), where Dop1a suppresses PL synthesis by binding to AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2), which is also localized at the NPCs. Loss of

Indexed as

biological sciences

Identifiers

PMID42164854
PMCPMC13186030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.