Evidence map›Paper›PMID 42164829›Full record

ArticleGastro hep advances2026

Heterogeneity of Muscularis Macrophages in the Stomach.

Gianluca Cipriani, Sihan Ji, Yuanhang Liu, Shefaa AlAsfoor, Magdalini Mischopoulou, Mohamed H Eldesouki, Mario D'Ambrosio, Lei Sha, David R Linden, Linda C Hsi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gianluca CiprianiEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Sihan JiEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Yuanhang LiuDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Shefaa AlAsfoorEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Magdalini MischopoulouEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Mohamed H EldesoukiEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Mario D'AmbrosioEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Lei ShaDepartment of Neuroendocrine Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
David R LindenEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Linda C HsiEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Madhusudan GroverEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Gianrico FarrugiaEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Funding

CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
Pathophysiology of Diabetic GastroparesisR01DK127992 · NIDDK · MAYO CLINIC ROCHESTER · PI FARRUGIA, GIANRICO, GROVER, MADHUSUDAN · 2021 to 2024
$2.2M
NIDDK NIH HHS R01 DK057061NIDDK NIH HHS R01 DK127992
6 · The paper itself

Abstract

Background and Aims: Macrophages in the muscle layers of the stomach (muscularis macrophages [MMs]) play a crucial role in regulating gastric motility and immune homeostasis by interacting with cells in their shared environment. The lack of knowledge of the subtypes of murine MMs that reside in the stomach limits a comprehensive understanding of their function and their involvement in disease development. Methods: In this study, we used single-cell sequencing analysis of CD45 Results: We distinguished different transcriptionally distinct gastric MMs with unique origin. Conclusion: Our study provides a fundamental understanding of the gastric tissue MMs heterogeneity.

Indexed as

CX3CR1Gastric Muscularis MacrophagesTissue Heterogeneity

Identifiers

PMID42164829
PMCPMC13185997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.