Evidence map›Paper›PMID 42164806›Full record

ArticleFrontiers in psychology2026

Independent associations of fatigue with cognitive function and quality of life in multiple sclerosis: a cross-sectional study.

Caterina Formica, Lilla Bonanno, Laura Culicetto, Antonino Lombardo Facciale, Edoardo Sessa, Carmela Rifici, Angelo Quartarone, Silvia Marino, Rocco Salvatore Calabrò, Desirèe Latella

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05783999 (Role of Muscle Vibration in Improving the Sense of Fatigue in Patients With Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05783999 naunknown statusnot on this map

Role of Muscle Vibration in Improving the Sense of Fatigue in Patients With Multiple Sclerosis

TypeinterventionalSponsorIRCCS Centro Neurolesi Bonino PulejoRan2021 to 2024Enrolled20ConditionsMultiple SclerosisArmsvibra plus
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caterina FormicaIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Lilla BonannoIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Laura CulicettoIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Antonino Lombardo FaccialeIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Edoardo SessaIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Carmela RificiIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Silvia MarinoIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.
Desirèe LatellaIRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS). Methods: Fifty-one patients with MS with a confirmed diagnosis of relapsing-remitting multiple sclerosis (RRMS), according to established diagnostic criteria were enrolled. Data were collected at a single time point to examine associations between fatigue, cognitive functioning, neurological disability, and health-related quality of life (QoL). All participants were submitted to a standardized neurological examination, Fatigue symptoms were assessed using the Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS) and Fatigue Scale for Motor and Cognitive Functions (FSMC). Cognitive profiles were evaluated with the Brief Repeatable Battery of Neuropsychological Tests (BRB-N), overall Quality of Life with the Multiple Sclerosis Quality Ff Life (MSQOL-54) and the Expanded Disability Status Scale (EDSS) to evaluate the disability status. Results: Our findings indicate a significative correlation between general FATIGUE and multiple QoL outcomes. Specifically, fatigue was strongly correlated with Health Perception ( Discussion: These results contribute to a more comprehensive understanding of disease burden in MS, highlighting fatigue as a key factor that interacts with multiple dimensions of patient functioning. Clinical trial registration: Identifier (NCT05783999).

Indexed as

cognitionfatiguemultiple sclerosisneurological disabilityquality of life

Identifiers

PMID42164806
PMCPMC13183650

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.