ReviewFrontiers in veterinary science2026
Nano/microencapsulation of feed additives for ruminal microbiome modulation and enteric methane mitigation in ruminants: a critical review.
Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Preparation of Targeted Delivery Materials and Their Application in Animal Production.Animals : an open access journal from MDPI · 2026Review
- Microbiome Engineering in Dairy Cattle: A Critical Review of Strategies for Disease Resistance, Productivity, and Sustainable Farming.Veterinary sciences · 2026Review
- Microencapsulation Strategies in Veterinary Medicine: Overcoming Gastrointestinal Barriers in Monogastric and Ruminant Species.Pharmaceutics · 2026Review
- Dietary inclusion of Morus alba leaves influences milk production and offspring growth performance in dairy goats.Tropical animal health and production · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The latest advances in nutrition, microbiology, and omics sciences are redefining strategies to improve health indices and productivity in livestock. A novel strategy focuses on the deliberate modulation of rumen and intestinal microbiome ecosystems, which, besides being complex, are crucial for animal performance. The use of feed additives, such as bioactive compounds derived from plants and probiotics, has a long tradition supported by their known antioxidant, anti-inflammatory, and antimicrobial properties, among others. However, their practical efficacy is often compromised by their high susceptibility to degradation. Environmental factors such as light, temperature, and harsh conditions like extreme pH and enzymatic and microbiota activity in the gastrointestinal tract of livestock can inactivate these compounds before they reach their site of action to exert the beneficial effects mentioned above. To solve this challenge, nanotechnology, specifically micro- and nanoencapsulation techniques, presents an innovative solution. These strategies can protect bioactive compounds, providing controlled release and targeted delivery to specific absorption sites. This design not only optimizes probiotic survival and bioavailability of bioactive compounds but also facilitates more effective modulation of ruminal and intestinal microbial communities. Recent evidence indicates that this modulation translates into tangible productive benefits, such as better nutrient absorption and higher energy efficiency, positively impacting parameters like milk production. Additionally, these encapsulation techniques improve the efficiency of these bioactive compounds to mitigate enteric methane emissions by altering ruminal fermentation patterns. This review critically analyzes the mechanisms, applications, and potential of encapsulation technologies in ruminant production. Special emphasis is placed on how these delivery systems represent a significant advance toward precision nutrition. Indeed, the efficacy of encapsulation for microbiota manipulation and toxicological challenges for safe and sustainable implementation is discussed. This critical review addresses the following questions: (1) Under what conditions could encapsulation offer real advantages over traditional additives in ruminant livestock? (2) Are there biologically significant differences between nano- and microencapsulation in the ruminal environment? (3) How are changes in the ruminal microbiota translated into productive performance and environmental impact? (4) What is the balance between productive and environmental sustainability benefits versus the toxicological risks of nanomaterials?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.