Evidence map›Paper›PMID 42164768›Full record

ArticleFrontiers in veterinary science2026

Integrative analysis of 16S rRNA sequencing and network pharmacology suggests protective effects of Sihuang Zhili Granules against APEC O78 challenge through gut homeostasis-related changes.

Zikai Guo, Xiaoran Wang, Danwei Cai, Zhennan Guo, Pi Cheng, Jianguo Zeng, Hua Liu, Yisong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zikai GuoHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Xiaoran WangHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Danwei CaiHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Zhennan GuoHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Pi ChengHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Jianguo ZengHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Hua LiuHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Yisong LiuHunan Provincial Key Laboratory of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Avian pathogenic Methods: This study combined microbiota analysis and network pharmacology to investigate the protective effects of Sihuang Zhili Granules (SH) against APEC O78 challenge. Results: Phenotypic analyses showed that SH treatment reduced mortality, partially improved growth-related performance, and alleviated histopathological lesions in the heart, liver, and spleen. At the mechanistic level, SH treatment was associated with increased mRNA expression of intestinal tight junction-related genes, including Discussion: These findings support the potential of SH as a candidate intervention for APEC O78-associated disease in broilers, while the precise microbiota-related and molecular mechanisms require further experimental validation.

Indexed as

anti-inflammatoryantimicrobial resistanceavian pathogenic Escherichia coligut microbiotaintestinal barrierSihuang Zhili Granules

Identifiers

PMID42164768
PMCPMC13183549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.