Evidence map›Paper›PMID 42164758›Full record

ArticleInternational journal of pharmaceutics: X2026

A synergistic nanozyme platform breaking the neuroinflammatory-oxidative stress cycle for extended pain relief.

Chengfeng Zhang, Zihan Xue, Jingyi Wang, Jianing Li, Wanlong Qian, Xueting Wang, Yong-Jing Gao, Zhongping Chen, Faming Wang, Yan Zhang

Abstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengfeng ZhangInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Zihan XueInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Jingyi WangInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Jianing LiInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Wanlong QianInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Xueting WangInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Yong-Jing GaoInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Zhongping ChenInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Faming WangInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.
Yan ZhangInstitute of Special Environmental Medicine, School of Public Health, Nantong University, Nantong 226019, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain represents a major public health burden that significantly compromises patient quality of life. Its persistence is driven by a vicious cycle of neuroinflammation and oxidative stress within the nervous system. Effective clinical management critically requires targeted therapeutics with long-lasting efficacy. Herein, we report a novel liposome-based co-delivery system (SeCQDs@Liposome-RA, SLR) encapsulating selenium-doped carbon quantum dots (SeCQDs) nanozymes and the potent anti-inflammatory agent Raddeanin A (RA). This platform was rationally engineered for synergistic antioxidant and anti-inflammatory actions.

Indexed as

Chronic painLiposomeNanozymeRaddeanin aReactive nitrogen and oxygen species

Identifiers

PMID42164758
PMCPMC13185767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.