ArticleCardiovascular diagnosis and therapy2026
Gradients after transcatheter aortic valve replacements are impacted by both body mass index and valve size: a retrospective cohort study.
Article in Cardiovascular diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Recommendations for future research on body mass index, valve sizing, patient-prosthesis mismatch, and post-transcatheter aortic valve replacement hemodynamics.Cardiovascular diagnosis and therapy · 2026Article
- Body mass index, valve size, and post-transcatheter aortic valve replacement hemodynamics: is patient-prosthesis mismatch the missing link?Cardiovascular diagnosis and therapy · 2026Article
- Are elevated post-transcatheter aortic valve replacement gradients in obese patients pathological or flow-mediated?Cardiovascular diagnosis and therapy · 2026Article
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Abstract
Background: Obesity is a common comorbidity among patients undergoing transcatheter aortic valve replacement (TAVR) and may influence valve hemodynamics. The impact of body mass index (BMI) and valve size on post-TAVR echo-derived gradients is not fully understood; however, it is clinically important for optimizing outcomes, particularly in high-BMI populations, where procedural success may be affected. This study aims to determine the relationship between BMI and post-procedural gradients. Methods: This retrospective cohort study was conducted at a single large academic medical center to study patients who underwent balloon-expandable TAVR between 2021 and 2023. Patients had pre-procedural computed tomography (CT) and echocardiographic data and completed a 30-day follow-up echocardiogram. Patients were stratified based on BMI (<30 Results: The groups were similar in demographics and clinical characteristics, except for age, which was significantly lower in the high BMI group (P<0.001). Low-BMI patients with large valves had significantly lower gradients than high-BMI patients with small valves (P=0.002). Among high-BMI patients, small valves were associated with significantly higher gradients than large valves (P=0.009). In low-BMI patients, gradients were similar regardless of valve size (P=0.16). In small valve patients, there was a trend for higher gradients in high versus low BMI (P=0.056). Conclusions: Both BMI and valve size impact 30-day echo-derived gradients after balloon-expandable TAVR. High BMI and small valves are associated with higher gradients. With larger valves, the impact of BMI on valve gradient is attenuated. Additionally, for low-BMI patients, valve size has less impact on gradients. This study suggests that BMI is a crucial factor impacting gradients, and suggests that future research into the role of weight loss in TAVR treatment should be conducted.
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