ReviewCardiovascular diagnosis and therapy2026
Cardiac magnetic resonance-derived left heart parameters in pulmonary hypertension: diagnostic and prognostic value-a narrative review.
Review in Cardiovascular diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objective: Patients with pulmonary hypertension (PH) exhibit left heart alterations, in morphology, function, and tissue characteristics, which may critically correlate with the pathophysiological mechanisms and prognosis of PH. However, a comprehensive review that summarizes the role of left heart parameters derived from cardiac magnetic resonance (CMR) in PH remains lacking. This review summarizes CMR-derived left heart morphological, functional, and tissue characterization parameters for PH diagnosis, classification, severity assessment, and prognosis, aiming to enhance evidence-based PH management. Methods: A literature search was performed on the PubMed and China National Knowledge Infrastructure (CNKI) databases for articles published between January 2000 and December 2024. Key search terms incorporated "pulmonary hypertension", "cardiac magnetic resonance", "left ventricle", "left atrium", "diagnosis", and "prognosis". Studies were deemed eligible if they investigated the association between CMR-derived left heart parameters and the diagnosis or prognosis of patients with PH. Key Content and Findings: This review synthesizes the evidence on key CMR-derived left heart parameters in PH. Left atrial volume index and left ventricular eccentricity index aid in the diagnosis and mortality prediction of PH. Left atrial active strain and left ventricular global strain serve as sensitive markers for identifying left ventricular dysfunction and predicting prognosis in PH patients, respectively. Ventricular interdependence parameters, such as ventricular mass index and septal angle, have been confirmed to correlate with hemodynamic parameters in PH. Furthermore, a key tissue characterization parameter-the right ventricular/left ventricular blood pool T2 ratio (RVT2/LVT2)-demonstrates significant value in assessing disease severity in chronic thromboembolic PH (CTEPH) and may serve as a novel non-invasive imaging marker for predicting prognosis in these patients. Conclusions: CMR-derived left heart parameters provide valuable insights for the diagnosis, classification, severity assessment, and prognosis of PH.
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