ArticleGland surgery2026
Circulating inflammatory indices refine prognostic stratification and complication risk in pancreatic cancer following radical surgery.
Article in Gland surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Systemic inflammatory biomarkers offer accessible and dynamic prognostic information in pancreatic ductal adenocarcinoma (PDAC). This study explores how circulating inflammatory indices enhance risk stratification and outcome prediction for PDAC patients undergoing radical resection. Methods: We analyzed 368 PDAC patients categorized by clinically relevant postoperative pancreatic fistula, resectability status, and Clavien-Dindo complication scores. Blood-based inflammatory indices were used to establish clinical risk profiles. Optimal cutoff values were determined using Youden's index. A prognostic nomogram was developed through multivariable regression and the least absolute shrinkage and selection operator (LASSO) regression analysis, and its predictive performance was evaluated using time-dependent receiver operating characteristic (ROC) curves against conventional staging systems. Results: Patients with borderline resectable (BR) PDAC and those with severe postoperative complications showed significantly elevated inflammatory indices. Those with inflammatory markers above optimal cutoff points had significantly poorer survival. A nomogram incorporating C-reactive protein (CRP), cancer antigen 199 (CA19-9) >500 U/mL, radiological resectability, and tumor size demonstrated superior prognostic accuracy over traditional staging systems and improved clinical decision-making. Conclusions: Circulating inflammatory biomarkers significantly improve prognostic assessment in patients with PDAC and can reflect the risk of surgical complications. Our findings support incorporating accessible blood-based inflammatory indices into multimodal risk stratification frameworks to guide personalized treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.